CSL Behring Monograph Berinert - page 8

7
List of Abbreviations
Abbreviation Abbreviation Definition Definition
AAE acquired angioedema
ACE angiotensin-converting enzyme
ADR adverse drug reaction
AE adverse event
B19V Parvovirus B19
C1 first component of
the complement cascade
C1-INH C1 esterase inhibitor
C1q first subcomponent of the C1 complex
of the classical pathway of complement
activation
C1NH human C1 esterase inhibitor gene
C2 second component of
the complement cascade
C3 third component of
the complement cascade
C4 fourth component of
the complement cascade
CJD Creutzfeldt-Jakob disease
FDA Food and Drug Administration
FXI coagulation factor XI
FXII coagulation factor XII
GI gastrointestinal
HAE hereditary angioedema
HAE-I hereditary angioedema type I
HAE-II hereditary angioedema type II
HAV Hepatitis A virus
HBV Hepatitis B virus
HCV Hepatitis C virus
HIC hydrophobic interaction chromatography
HIV Human immunodeficiency virus
HMWK high molecular weight kininogen
I.M.P.A.C.T. International Multi-centre Prospective
Angioedema C1-Inhibitor Trials
IU international units
IVR in vivo recovery
KKS kallikrein-kinin system
MASP mannose-binding protein-associated
serine protease
NAT nucleic acid amplification technique
PCR polymerase chain reaction
PK pharmacokinetic(s)
pnfC1-INH pasteurized, nanofiltered
C1 esterase inhibitor (Berinert® )
PREHAEAT Novel Methods for Predicting, Preventing,
and Treating Attacks in Patients With
Hereditary Angioedema (includes a European
register of HAE patients in 10 countries)
PRV Pseudorabies virus
QSEAL Quality Standards of Excellence,
Assurance Leadership
rhC1-INH recombinant human transgenic
C1 esterase inhibitor
sCJD sporadic Creutzfeldt-Jakob disease
SD standard deviation
SERPING1 human C1 esterase inhibitor gene
t-½ terminal half-life
Tmax time to maximum plasma concentration
vCJD variant Creutzfeldt-Jakob disease
Vss median volume of distribution
at steady state
WAO World Allergy Organization
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