53
MOA
Figure 26 – Berinert
®
Mechanism of Action as a Serpin
C1-INH acts as a
pseudosubstrate,
attracting and trapping
the target protease at the
reactive center loop.
The single chain is cleaved,
and the molecule springs
closed like a mousetrap.
C1-INH and the
target protease bind
covalently, and a fourth
beta-sheet is created.
