46
6.0 Berinert
®
Dosage and Administration
Chapter 6 Highlights
•
Berinert
®
comes as a complete adminis-
tration set, including product, solvent,
filter transfer device (Mix2Vial
™
)
*
,
disposable syringe, venipuncture set,
2 alcohol swabs, and plaster.
•
The Mix2Vial
™
filter transfer set simpli-
fies preparation and, with correct use,
eliminates the risk of needlestick injuries
during reconstitution.
•
The recommended dose of Berinert
®
is
20 IU/kg body weight, administered by
intravenous injection for the treatment
of acute attacks in patients with HAE.
•
It is recommended that Berinert
®
be ad-
ministered by slow intravenous injection
at a rate of 4 mL/minute.
•
A 70-kg patient would require 1,400 IU
or 28 mL, infused over 7 minutes.
6.1 Dosage Forms and Strengths
Berinert
®
is a lyophilized concentrate (500 IU) in a single-
use vial for reconstitution with 10 mL of sterile water for
injection (solvent).
As shown in Figure 23, Berinert
®
comes with a complete
administration set. All Berinert
®
packaging and compo-
nents are latex-free.
*
* The administration set and Mix2Vial™ are supplied in most countries.
•
500 IU Vial of Berinert
®
•
10 ml Vial of Sterile Water
for Injection (Solvent)
•
1 Mix2Vial
™
Filter Transfer Device
•
1 Disposable 10 ml Syringe
•
1 Venipuncture Set
•
2 Alcohol Swabs
•
1 Plaster
Product Pack:
Administration Pack*:
Figure 23 – Berinert
®
Comes With a Complete Administration Set
