30
Although no controlled studies with pregnant women have
been published, C1-INH concentrate is judged to be safe
and efficacious during pregnancy and lactation for either
prophylaxis or acute therapy. The International Consensus
Algorithm agrees in that C1-INH concentrate is the safest
prophylactic agent during pregnancy.
11
3.45 Treatment of Pediatric Patients
The recommendations from the International Consensus
Algorithm also apply, with some adaptations, to children.
In general, C1-INH is recommended for acute attacks and
for short- and long-term prophylaxis.
11,71
In the consensus on therapeutic strategies for children
and adolescents with HAE, experts conclude that plasma-
derived C1-INH concentrate is the best available option
for treatment of acute attacks and short- and long-term
prophylaxis for pediatric patients.
69
As fixed doses established for adultsmight not be appropriate
for patients younger than 18 years of age, experts strongly
advocate taking body weight into account for the treatment
of pediatric patients with C1-INH concentrate.
69
